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Objective To explore the method of chemical synth esis of L-alanyl-L-glutamine dipeptide.

目的探讨L-丙-L-肽的化学合成方法。

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Osmosis-遗传

CAG codes for the amino acid glutamine, so people with Huntington disease patients will have 36 or more glutamines in a row in the huntingtin protein.

因为CAG序列对应的是谷氨胺(氨基),所HD患者体内,huntingtin蛋白质上会有36个上连续的谷氨胺。

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Osmosis-神经

The specific way in which extra glutamines causes the disease's symptoms isn't fully understood but the abnormal protein seems to aggregate within the neurons of the cerebellum and the spinal cord, causing them to die.

过多谷氨胺导致疾病症状的具体机制尚未完全清楚,但异常蛋白质似乎聚脑和脊髓的神经元内,从而导致神经元的死亡。

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In some cases, the involved gene contains a triplet repeat where the nucleotides C, A and G are repeated multiple times in a row and since CAG codes for the amino acid glutamine, the encoded protein will have multiple extra glutamines in a row.

某些情况下,涉及的基因包含一个三联体重复序列,即核苷C、A和G连续重复多次;由于CAG编码谷氨胺,编码的蛋白质将具有连续多个额外的谷氨胺。

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