Capsule subglobose, leathery, pallid, cinereous-luteous or cinereous-brunescent, surface usually with densely squarrulose macula or smooth, loculicidally dehiscent.
This is because the part of the occipital lobe in charge of the macula gets blood from both the posterior cerebral artery as well as the medial cerebral artery.
Ophthalmologists may be the first to consider TSD by finding a " cherry red spot" in the macula of the eye, which results from GM2 buildup in the retinal cells around the central macular area.
So, in the case of hypovolemia and hypotension, the macula densa cells sense the low sodium and chloride levels and send a signal over to the juxtaglomerular cells which are located in the wall of the afferent arteriole.