Using ortho-bis(porpargyl alcohol) derivatives as starting materials, we employed sulfenyl or sulfinyl chloride under base condition to generate bis-allene intermediates.
The isomers dostribution of ortho-and para-toluenesulfonamide are successfully determined by high performance liquidchromatography (HPLC) . The results are compared with ultraviolet-spectroscopy (UV).
In the related "amide route" starting from 2-chloroisonicotinic acid, 41 ,a secondary amide directing group was used to facilitate the ortho lithiation of the pyridine 3-position.
This method not only lowcrs the temperature of labelling ortho-iodo-hippuric acid, speeds up the reaction and gives high yield, but aslo suits the requirement of large scale production.