Normally, the liver and kidneys produce a tiny hormone called thrombopoietin which binds to hematopoietic cell receptors.
正常情况下,肝脏和肾脏会合成一种叫做促小板生成素的激素,可以结合。
Cells can also develop mutations in the thrombopoietin receptor, MPL, or in the chaperone protein, Calreticulin or CalR.
内的促小板生成素(MPL)或伴侣蛋白/钙网蛋白(CalR)也可以发生突变。
Now, when there’s a genetic mutation in CalR, the signalling pathway remains active all the time, and that means that platelets keep getting produced even in the absence of thrombopoietin.
在CalR发生基因突变后,信号通路处于持续激活状态,这就意味着即使没有促小板生成素,小板也会持续生成。
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