Individuals with tuberous sclerosis have a mutation in either the gene TSC1 or TSC2, and these mutations have an autosomal dominant inheritance pattern.
These developmental masses happen frequently in patients that also have tuberous sclerosis —a genetic disorder causing these non-cancerous masses to form in various tissues.
Symptoms of tuberous sclerosis are often related to the hamartomas in the brain which cause problems like seizures, learning difficulties, and cognitive deficits.