ketal

1.Doxifluridine was facilely synthesized from 5-fluorouracil in overall yield of 54.6% via trimethyl silylation, condensation, saponification, ketal formation, iodation, hydrogenolysis and hydrolysis.

以5-氟尿嘧啶为料经硅醚化、四乙酰核糖缩、皂化、酮缩醇形、碘化、氢解及水解等反应去氧氟尿苷。本法工艺简便、条件、料易得、本低,总收率达54.6

2.Benzalacetone 1,2-propylene glycol ketal was synthesized from benzalacetone and 1,2-propylene glycol in the presence of ptoluene sulphonic acid.

以对甲苯磺酸为催化剂,通过苄叉丙酮与-1,2-丙二醇反应苄叉丙酮-1,2-丙二醇缩酮。