1.Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

1.方法以克拉霉素为起始原料,经水解、乙酰、碳、、脱碳、酰、基甲和合等反应合成目标合物。

2.The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

2.组蛋白乙酰和去乙酰由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰酶负责。