To detect the expression of adrenocorticotropin(ACTH) in adrenal cortex hyperplasia, and to explore the mechanism of adrenal cortex glomorulosa zona hyperplasia development.
Secondary hypoadrenalism, or ACTH deficiency hypoadrenalism, is caused by diseases of the pituitary gland, which lead to adrenal failure as a secondary effect.
Methods Clinical and follow up data were summarized for 42 children with adrenogenital syndrome, including 30 cases of congenital adrenal hyperplasia (CAH) and 12 cases of adrenal cortex tumor.
In both adrenal adenomas and carcinomas, the cells of the zona fasciculata within the adrenal cortex start dividing abnormally and secrete excess cortisol.
The sympathetic neurons releases norepinephrine, also called noradrenaline, and the cells of the adrenal medulla release norepinephrine and epinephrine, also called adrenaline.
It can also lead to low adrenocorticotropic hormone levels and subsequent adrenal gland insufficiency caused by a decrease in sodium and blood glucose levels.
In the lumbar region, neural crest cells differentiate into the cells of the adrenal medulla, the inner part of the adrenal gland that sits atop the kidneys.
Another common cause of endogenous Cushing syndrome is tumors of the adrenal glands that make excess cortisol - like adrenal adenomas, which are benign tumors, and adrenal carcinomas, which are malignant tumors.