In ankylosing spondylitis there’s chronic inflammation of the intervertebral joints and the facet joints of the spine.

患有强直性脊柱炎时，椎间盘和关节突关节内存在炎症。

Most individuals with ankylosing spondylitis have the gene HLA-B27, which is a gene that encodes for a specific type of MHC class I molecule.

强直性脊柱炎患者都携带HLA-B27基，该基能编码一种特定的MHC Ⅰ类。

If ankylosing spondylitis affects the sacroiliac joints it typically causes buttock pain, and if it affects the cervical or thoracic region it can cause neck or back pain and stiffness.

如果强直性脊柱炎累及骶髂关节，通常会引起臀部疼痛；如果累及颈椎或胸椎，则会引起颈部和背部的疼痛和僵硬。

So ankylosing spondylitis is a chronic inflammatory disease that affects the vertebral joints and makes the spine really stiff, but can also cause inflammation in other parts of the body like the eyes and blood vessels.

此，强直性脊柱炎是一种累及脊柱关节并使脊柱变得僵直的慢性炎症性疾病；它也会累及身体其他部位，如眼部和血管。