1.Objective: To explore the effect of cholecystokinin on electricity activity of gastric distention related neurons in the nucleus of tractus solitarius.
2.Less energy expenditure makes you more lethargic, less cholecystokinin means more hunger, less leptin signalling means more hunger and more ghrelin also means you're hungrier.
3.The cholecystokinin makes its way to the gallbladder, the thin walled, green sac snuggling up against the liver, and signals it to squeeze out some bile through the cystic and bile ducts into the small intestine.
4.As an October 2011 study in the New England Journal of Medicine says: " Caloric restriction results in acute compensatory changes, including profound reductions in energy expenditure and levels of leptin and cholecystokinin and increases in ghrelin and appetite."