From there, four molecules of porphobilinogen condense together to form hydroxymethylbilane with the help of porphobilinogen deaminase.

卟原的四个分子一并压缩构成，羟甲卟原脱氨酶的辅助下。

Note that porphobilinogen deaminase is sometimes called uroporphyrinogen I synthase or hydroxymethylbilane synthase, or HMBS for short.

卟原脱氨酶有时被为尿卟啉原I合成酶或羟甲合成酶，缩略为HMBS。

The majority of individuals with the HMBS gene mutation and a deficiency of porphobilinogen deaminase are asymptomatic.

HMBS因突变及缺乏卟原脱氨酶的人群大部分没有症状。

From there, four molecules of Porphobilinogen condense together to form Hydroxymethylbilane with help of Porphobilinogen deaminase.

从这里开始，四分子色原色原脱氨酶的作用下凝聚一起，形成羟甲色烷。

Now individuals with acute intermittent porphyria have a mutation of the HMBS gene which codes for the enzyme porphobilinogen deaminase.

急性间歇性卟啉病的患者HMBS因的突变；该因编码卟原脱氨酶。

All right, as a quick recap, acute intermittent porphyria is an autosomal dominant disorder caused by a deficiency of the enzyme porphobilinogen deaminase in the heme synthesis pathway.

好，快速回顾一下：急性间歇性卟啉病是常染色体显性疾病，由血红合成途径中缺乏卟原脱氨酶导致。