So the Prader-Willi patients with deletions that encompass OCA2 can have a light complexion.

因此OCA2基因缺失的普拉德-威利综合征患者肤色较浅。

With gene editing, targeted changes are made like deletions and insertions right in an organism's genome.

通过基因编辑，可以在生物的基因组上做出删除、插定的改变。

Most of these gene mutations are deletions or duplications of one or more exons, and a small amount are point mutations.

基因突变大多数为一个或多个外显子的缺失或重复，小部分点突变。

The most common one is a deletion on the paternal genes spanning Prader-Willi region.

最常见的原因父源染色体相关基因的缺陷。

Many deletions also include a nearby gene called OCA2, which codes for a pigment that gives color to eye, hair, and skin.

其中也包括近基因OCA2基因的缺陷；OCA2编码眼睛颜色、发色和肤色的基因。

And alpha thalassemia is caused by mutations in the alpha genes, most commonly a gene deletion.

而α地中海由α基因变异引起的，最常见的原因基因缺失。

All right, as a quick recap: alpha thalassemia is an autosomal recessive disorder caused by deletion of alpha globin genes on chromosome 16.

得！快速回顾一下：α地中海一种常染色体隐性遗传病，由16号染色体上的α珠蛋白基因缺陷引起。

The cause of this TA is unknown, although a lot of cases seem to be associated with 22q11.2 deletion syndrome, also known as DiGeorge Syndrome.

TA的诱因尚不明确，但不少病例似乎与22q11.2染色体微缺失综合征（或称DiGeorge综合征）相关。

The American Car Rental Association is part of a coalition asking the U.S. Congress to pass a law to govern data deletion.

美国汽车租赁协会也要求美国国会通过一项法律来管理数据删除。

A public figure's stupid tweets are more likely than most to be screen-captured by others, so that even deletion won't help (and may suggest a guilty conscience).

相较于大多数人，公众人物欠妥的推文要更容易被其他人截屏，所以即使删除也无济于事（还可能昭示博主心里有鬼）。

Cutting a DNA sequence in your genome also disrupts the function of the cut gene, typically, by causing the insertion and deletion of random mixtures of DNA letters at the cut site.

切割基因组中的DNA序列也会破坏切割基因的功能，通常，通过在切割位点插和删除随机的DNA字母混合物。

Delta means a deletion, and the F (which can also be written as “Phe”) is short for phenylalanine, and the 508 is the five hundred and 8th amino acid in the CFTR protein.

∆代表缺失，F（也可写作Phe）代表苯丙氨酸，508指CFTR蛋白上第508个氨基酸。

So both an MYCN amplification or ALK gene fusion, where the oncogene is “turned on, ” or a PHOX2B and chromosome 1 and 11 deletions, where tumor suppressor genes are “turned off, ” can potentially cause uncontrolled cell growth.

因此，MYCN基因扩增或ALK基因的融合，即致癌基因被激活，或PHOX2B与1号、11号染色体缺失，即抑癌基因的失活，都可能导致细胞生长不受控制。