Dentin matrix protein 1 (DMP1) is expressed in both pulp and odontoblast cells and deletion of the Dmp1 gene leads to defects in odontogenesis and mineralization.
The outer wall of the pulp, contains odontoblasts which are cells that secrete a bonelike substance called dentin, which is filled with protein and minerals.
At that point, the bacteria, which are normally too big to fit through the enamel diffusion channel, can penetrate all the way through the enamel to the dentin.