Before the treatment, the diagnostic uterine curettage were performed to see whether the pathologic result is the pute hyperplasia of the endometrium or not.
So having high levels of estrogen will cause the endometrium undergoes hyperplasia, leading to increased risk of developing type 1 endometrial carcinoma.
It’s followed by the proliferative phase, during which the rising levels of ovarian estrogen make the functional layer of the endometrium thicken and sprout endometrial glands.
Next are endometrioid tumors which come from endometrium-like cells which is ectopic, meaning they’re out of place, because those sorts of cells are usually found in the endometrium.
The endometrium is itself made up of a single layer of simple columnar epithelium, which has ciliated and secretory cells, that sit on top of connective tissue, or stroma.
During puberty, the monthly menstrual and ovarian cycles begin, which is when the endometrium, or inner lining of the uterus, goes through cyclic changes in response to the ovarian hormones.
Amenorrhea can occur because there is so much scar tissue that there’s no functional endometrium left, or because the presence of scar tissue makes the endometrium refractory to hormonal stimulation.
During the follicular phase of the menstrual cycle, the endometrium thickens in case fertilization occurs, during the luteal phase, spiral arteries emerge to bring more nutrients to support the thick endometrium.