It's a humblingly serious problem and might even be what dooms the relationship itself.

这是一个令的严重问题，甚至是导致这段关系身失败的原因。

A partner may be only half-right, quite often maddening and properly disappointing in certain areas, but – humblingly – still more satisfying than being alone.

伴侣对了一半，在某些方面常常令抓狂和适当地失望， 但——谦虚地——仍然比独处更令满意。