Methods To observe the effect of emodin on delayed type hypersensitivity (DTH) induced by dinitrofluorobenzene (DNFB), mice were administered emodin by i.p.
This is considered a type II hypersensitivity reaction, although it isn’t fully understood why some of these antibodies targeting specific cells and molecules develop.
Myasthenia gravis is a type II hypersensitivity disorder where the body produces antibodies that most commonly target nicotinic acetylcholine receptors on the surface of muscle cells.
This is thought to be a type I or type IV hypersensitivity reaction, and is typically a response to a medication like NSAIDs, penicillin, and diuretics.
IgA nephropathy is therefore a type III hypersensitivity disorder, meaning that pathology and inflammation will happen at the site the immune complexes deposit, not where they are formed.
The reason this happens is that in type 1 diabetes there is a type 4 hypersensitivity response or a cell-mediated immune response where a person’s own T cells attack the pancreas.