In metastatic melanoma a generalized darkening of the skin (diffuse melanosis cutis) may occur.Usually melanuria is also present.

转移素瘤患者可发生全肤变（肤播散变），通常存在尿。

Conclusion Melanosis coli is inflammation,benign,reversibility chromatosis as characteristic,the disease is related to taking anthracene for long time constipation.

结论结肠变病是结肠的一种、良、可逆的以色素沉着为特征的病变,该病的发生与长期便秘服用蒽琨类泻剂有关。