1.Rhein,a main constituent of rhubarb, is a well-characterized anti-inflammatory agent with recognized utility in a range of inflammatory diseases such as ostarthritis, diabetic nephropathy etc.
4.IgA nephropathy, sometimes known as Berger disease, is the most common form of nephropathy worldwide, and it happens when an abnormal IgA forms and deposits in the kidneys, causing kidney damage.
5.IgA nephropathy is therefore a type III hypersensitivity disorder, meaning that pathology and inflammation will happen at the site the immune complexes deposit, not where they are formed.
6.Those immune complexes can also be visualized on immunofluorescence, although one important finding that can help differentiate from other immune-complex mediated nephropathies is that these complexes involve IgA.
7.Individuals with chronic gout are also at an increased risk for developing kidney stones made of uric acid, as well as urate nephropathy, which is when urate crystals deposit in the interstitium of the kidney.