Novel oncogene with kinase-domain (NOK) can activate multiple mitogenic signaling pathways including the janus kinases (JAK) and signal transducer and activator of transcription proteins (STAT).
摘NOK能激活包含JAK-STAT信号通路在内的多种促细胞有丝分裂信号通路。
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So both an MYCN amplification or ALK gene fusion, where the oncogene is “turned on, ” or a PHOX2B and chromosome 1 and 11 deletions, where tumor suppressor genes are “turned off, ” can potentially cause uncontrolled cell growth.
此,MYCN扩增或ALK的融合,即致被激活,或PHOX2B与1号、11号染色体缺失,即抑的失活,都可能导致细胞生长不受控制。