A recombinant HGP44 inhibited HIV-1 replication at a 50% effective concentration of approximately 2.5 micromolar, the researchers note, somewhat less potently than did P. gingivalis extracts.
The recombinant protein vaccine is the third type of COVID-19 vaccine that China has provided to other countries, following inactivated vaccines and adenovirus vector vaccines.
The developers say the level of neutralizing antibody elicited by the vaccine is comparable to other COVID-19 recombinant protein vaccines and mRNA vaccines in the world.
Chronic treatment for multiple sclerosis includes immunosuppressants like recombinant beta-IFN which decreases the level of inflammatory cytokines in the brain and increases the function of T regulatory cells.
Propagation of the host organism containing the recombinant DNA forms a set of genetically identical organisms, or a clone. This process is hence known as DNA cloning.
Prior to the advent of gene cloning and protein production via recombinant DNA techniques, it was necessary to purify these molecules from animal tissues or donated human blood.