As the estrogen is combined with osteoclast, it can inhibit the activity of lysomal enzyme, inhibit bone resorption and decrease the ability of osteclast on forming cavate in bone slice.
This is caused by increased bone resorption, which is a process that breaks bones down, eventually fast enough that it outweighs the rate of new bone growth.
Parathyroid hormone is produced by the parathyroid glands in response to low serum calcium, and it increases bone resorption to release calcium into the bloodstream.
On the other hand, calcitonin is produced by the thyroid gland in response to high serum calcium, so it opposes the action of PTH - therefore promoting bone formation and decreasing bone resorption.