Chronic vesicoureteral reflux can cause pyelonephritis, or inflammation of the kidney, and renal scarring, or fibrosis which damages the kidney tissue.
His insecurities were rooted in his sickly childhood and exacerbated by premature baldness, pockmarked skin, prominent nose and later, scarring from gunshot wounds.
In severe cases, severe destruction and scarring can lead to an empty sella turcica which is when the pituitary gland shrinks and flattens into the skull.
So then, your immune system kicks in, sending over a bunch of white blood cells, and the result is inflammation, maybe even pneumonia, or scarring of the lung tissue.