Finally, children with sickle cell typically get prophylaxis with penicillin and an additional polysaccharide vaccine against Streptococcus pneumoniae to help prevent sepsis and meningitis with encapsulated bacteria.
Fever isn't usually a symptom of intussusception, but in serious cases, like with infarction, the intestines can tear and release bacteria into the body cavity, causing sepsis and fever.
If not treated, both the first and second type can transition into the third type which is disseminated infection, where herpes virus causes sepsis and failure of various organs including the heart and brain.