The outermost layer is the zona glomerulosa, and it’s full of cells that make the hormone aldosterone.

最外层是球带，了产生醛固酮的细胞。

This causes a decrease in CRH and ACTH, which in turn, shuts down cortisol production from the zona fasciculata.

这会降低CRH和ACTH，反过来阻止束带制造皮质醇。

In both adrenal adenomas and carcinomas, the cells of the zona fasciculata within the adrenal cortex start dividing abnormally and secrete excess cortisol.

在肾上腺腺瘤和肾上腺癌中，肾上腺皮质里束带的细胞开始异常裂并泌过多皮质醇。

With less ACTH floating around, the zona fasciculata gets less stimulation to make cortisol, and eventually, cortisol levels go back down to the normal range again.

随着ACTH减少，束带受刺激产生皮质醇减少，最后，皮质醇水平降低到正常范围。

Second, cortisol starts cross-reacting with mineralocorticoid receptors, which normally only binds a related steroid hormone - mineralocorticoids which are secreted from the zona glomerulosa layer of the adrenal cortex.

第二，皮质醇对盐皮质激素受体产生交叉反应；此类受体一般只与一种相关的类固醇激素结合，即从肾上腺皮质的球带层泌的盐皮质激素。

The adrenal cortex is the outer part of the adrenal gland and is subdivided into three layers- the zona glomerulosa, the zona fasciculata, and the zona reticularis.

肾上腺皮质是肾上腺的外层部，皮质又为三层：球带、束带和网带。

The most common primary cause is called idiopathic hyperaldosteronism, because the zona glomerulosa has an increase in the number of cells secreting aldosterone, but it’s not really clear why this happens.

这是由于球带泌醛固酮的细胞数量增加，但目前尚不清楚为什么会发生这种情况。

In primary hyperaldosteronism, the main problem is that zona glomerulosa cells secrete high levels of aldosterone, and that aldosterone has a negative feedback effect on renin, and so it actually inhibits renin production.

在原发性醛固酮增多症中，主要问题是球带细胞泌高水平的醛固酮；醛固酮对肾素有负反馈作用，因而实际上抑制肾素生成。