acidylation

Levocetirizine Dihydrochloride was prepared from benzoyl chloride by acidylation,hydrogenation,cyclization with an overall yield of 8.05%.

以苯甲酰氯为原料,经酰化,还原,环合等反应合成左旋西替利,反应总收率为8.05%。

, and the production and application of it were described.At present, the methods of synthesizing N-formylmorpholine are formic acid method, methyl formate method, carboxide acidylation method, etc.

目前N-甲酰吗啉的要生产方法有甲法、甲甲酯法合成法等,其中甲法生产工艺最优,有较好的工业应用前景。