bromotoluene

1.cyano 4’ methyl phenylbenzene, a key intermediate of Sartan drug, was synthesized from 4 bromotoluene and 2 bromobenzonitrile in the present of cuprous bromide as a catalyst. The yield is 50%.

以溴化亚铜为催化剂,将邻甲腈与对溴甲偶制备了合成沙坦的关键中体2氰4′甲,收率50%。