N-phosphoryl amino acids could be catalyzed by imidazole to result in solvolysis such as ester exchanges on phosphorus, esterification, formation of peptides and N→O migration of the phosphoryl group.
咪唑对化氨酸的活化反应具有较强的催化作用,化丝、苏氨酸在咪唑催化下不仅能发生剂解反应,如上酯交换、羧活化成酯、成肽及的N→O迁移等,而且还会发生分子内环化反应;