quinolone

High-level quinolone resistance require mutations in both DNA gyrase gene and topoisomerase Ⅳ gene. ② Bacterial cell wall is the barrier for the entry of antibiotics.

高水平的耐药由DNA回旋酶和构酶Ⅳ发生变造成。② 细菌细胞壁是抗生素进入的屏障。

Difloxacin is the fluorinated quinolone approved for use in veterinary only. compared to ciprofloxacin,it provided with better pharmacokinetical and pharmacodynamical feature.

二氟沙星属于兽医专用药物，并且有优于环丙沙星的药动学征，具有良好的应用前景。

Quinolone is known as broad antibacterial spectrum,high potency,no crossing drugresistance with other antibacterial drugs,and easy and low cost to administer.

喹诺酮类药物具有抗菌谱广、抗菌活性强、给药方便,与常用抗菌药物无交叉耐药性、价格低等。

Finally, we gained four esterifiable quinolone analogues (compounds 22 to 25) by modifying the structures of compound 3, 14 and 16 on 3 position.

利用所合成的化合物3，14，16为模板，对它们的3位羧基进行了酯化反应合成了4个喹诺酮酯类化合物：化合物22—25。