superhelix

After absorption, prulifloxacin is metabolised by esterases to ulifloxacin, which inhibits the formation of superhelix, cell division and reproduction by interfering the DNA toposomerase.

本品为前体药,其活性代谢产物通过阻碍DNA拓扑异构酶使细菌DNA无法形成超螺旋,致细菌细胞无法裂繁殖。