As the estrogen is combined with osteoclast, it can inhibit the activity of lysomal enzyme, inhibit bone resorption and decrease the ability of osteclast on forming cavate in bone slice.
Ok, now, when osteoclasts break down bone faster than the osteoblasts can rebuild it, it results in the lowering of the bone mass and eventually in osteoporosis.
Finally, medications like denosumab, which is a monoclonal antibody that inhibits osteoclasts, and raloxifene, which is a selective estrogen receptor modulator, can be used for postmenopausal osteoporosis.
With senile osteoporosis, on the other hand, it’s believed that osteoblasts just gradually lose the ability to form bone, while the osteoclasts keep doing their thing unabated.
The tumor cells arises from osteoclasts cells, but then develop into cells that have numerous nuclei - typically over 50 nuclei - so you can think of them as destructive little giants.